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In Phase 3 TRIUMPH-1 data, diarrhea was reported in 25.2% to 34.1% of participants taking retatrutide, constipation in 23.8% to 26.1%, and vomiting in 10.6% to 25.3%, compared with lower rates among participants receiving placebo

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The reassuring part is that the underlying mechanism overlaps with the other GLP-1 medications